Tytuł: | A simple stripping voltammetric method for the determination of a new anticancer prodrug in serum. |
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Autorzy: | [AUT.] Anna Stępniowska , Małgorzata Sztanke , Tomasz Tuzimski , Mieczysław Korolczuk , Krzysztof Sztanke . |
Szczegóły: | BIOSENSORS & BIOELECTRONICS 2017 Vol. 94, 584-588 |
Streszczenie: | The determination of ethyl [4-oxo-8-(3-chlorophenyl)-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl]acetate (ETTA), a new anticancer prodrug, using adsorptive stripping voltammetry (AdSV) was described for the first time. This method is based on adsorptive/reductive behaviour of ETTA at an in situ plated bismuth film electrode (BiFE) as a sensor. A number of experimental variables (e.g., a composition and pH of the supporting electrolyte, the conditions of bismuth film deposition, an accumulation potential and time, the scan rate, etc.) were thoroughly studied in order to achieve a high sensitivity. Experimental results under optimized conditions revealed an excellent linear correlation between the monitored voltammetric peak current and the ETTA concentration in the range of 2–50 μg L−1 following an accumulation time of 300 s. The limit of detection (LOD) for ETTA following 300 s of an accumulation time was 0.4 μg L−1. The proposed facile, sensitive and inexpensive method was successfully applied to the determination of ETTA in serum. The investigated prodrug was extracted from serum using SPE method. |
Strona WWW: | http://www.sciencedirect.com/science/article/pii/S095656631730221X |
DOI | 10.1016/j.bios.2017.03.053 |
BPP ID: | (46, 41476) czyli wydawnictwo ciągłe o ID = 41476 |
PBN UID: | 5ebff5a8ad49b31ccec26c27 |
PBN ID (historyczne): | 41476 |
Rok: | 2017 |
Charakter formalny: | Artykuł w czasopismie |
Język: | Angielski |
Typ MNiSW/MEiN: | praca oryginalna |
Punkty MNiSW/MEiN: | 40,00 |
Impact factor: | 8,173 |
Rekord utworzony: | 28 kwietnia 2017 14:55 |
Rekord zaktualizowany: | 8 listopada 2021 08:44 |