Tytuł: | Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model. |
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Autorzy: | [AUT.] Ewelina Cholewińska , Jerzy Juśkiewicz , [AUT. KORESP.] Katarzyna Ognik . |
Szczegóły: | JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 2018 Vol. 48, s. 111-117 |
Streszczenie: | The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two differentchemical forms (carbonate and nanoparticles) on metabolic, immune and antioxidant status in a rat model. Fiveexperimental treatments (8 rats in each) were used to test different dosages of Cu added to the diet (standard−6.5 mg/kg, half the standard dosage−3.25 mg/kg, and no added Cu as a negative control) and two sources ofadded copper (standard−CuCO3and copper nanoparticles−CuNPs). Blood and urine samples were collectedfrom all the animals after four weeks of treatment. Metabolic and immune parameters were determined in bloodand urine samples. The study has shown that a dietary Cu deficiency (negative control) decreases rat’s plasmalevels of Cu, Fe, CREAT, BIL and IL-6, whereas reducing the level of Cu from the recommended 6.5 mg/kg to3.25 mg/kg decreases only the plasma concentration of TG, IgE and IL-6. Replacing CuCO3with CuNPs in ratdiets affects their metabolism, as indicated by decreased Ca, CREAT, BIL, ALB and IL-6 plasma levels. To sum up,CuNP added to a diet of rats have a more beneficial effect on metabolic indices (indicative of kidney and liverfunction) and inhibit inflammatory processes more effectively than CuCO3. |
Strona WWW: | https://www.sciencedirect.com/science/article/pii/S0946672X1830018X |
DOI | 10.1016/j.jtemb.2018.03.017 |
BPP ID: | (46, 43584) czyli wydawnictwo ciągłe o ID = 43584 |
PBN UID: | 5ec00669ad49b31cced98fe9 |
Rok: | 2018 |
Charakter formalny: | Artykuł w czasopismie |
Język: | Angielski |
Typ MNiSW/MEiN: | praca oryginalna |
Punkty MNiSW/MEiN: | 20,00 |
Impact factor: | 2,895 |
Rekord utworzony: | 23 marca 2018 07:52 |
Rekord zaktualizowany: | 15 listopada 2021 13:37 |