The transmission of pathogens between wildlife and livestock is globally recognized as a threat to the livestock industry, as well as to humans health. The frequency of emerging (and re‑emerging) infectious diseases has increased, posing new questions about their epidemiology and wildlife reservoirs. Anthropogenic landscape modifications create new interfaces between livestock and wildlife, potentially exacerbating processes that favor pathogens transmission. Deer and roe-deer can serve as reservoirs for a number of bacteria, viruses, and parasites, transmissible to humans and domestic animals through direct interactions through contaminated food or indirectly, through contaminated environment. Transmission of the diseases by cervids, could also negatively impact their effective control, management or eradication resulting in prolonged epidemics in the livestock. This article presents major issues on the increasing risks for both, farm animals and humans, resulting from the infectious diseases transmission from the wildlife reservoirs.