Phenolic compounds (PCs) are widespread secondary metabolites with potent biological activity. Their sources are mainly plants from cultivated and natural states, providing valuable protective and health-promoting extracts. The wide biological activity of PCs (antioxidant, anti-inflammatory, antimicrobial, antiatherosclerotic, antidiabetic, antiallergic, prebiotic, antimutagenic) means that new sources of PCs are constantly being sought, as exemplified by extracting these compounds from tissue culture or agricultural by-products. Plant phenols show marked qualitative and quantitative variation not only at different genetic levels (between and within species and clones) but also between different physiological and developmental stages. Assessing genetic and seasonal variations in phenolic content and activity allows for selecting the best time to harvest the plant. Learning about the causes of PCs’ variability and putting this knowledge into practice can significantly increase PCs’ yields and extract the most valuable compounds. The health-promoting properties resulting from consuming products rich in plant PCs are undeniable, so it is worth promoting high-phenolic products as a regular diet. This paper presents an overview of different sources of PCs for use as potential therapeutic alternatives. Additionally, factors of variation in the phenolic complex at the genome and ontogeny levels, relevant in practical terms and as a basis for further scientific research, are presented.