The aim of our study was to determine the effects of aeruginosin 98 A (ARE-A), microginin-FR1 (MG-FR1), anabaenopeptin-A (ANA-A) cylindrospermopsin (CYL) and their binary and quadruple mixtures on the survival and the levels of oxidative stress biomarkers in Daphnia magna: total glutathione (GSH), catalase (CAT), dismutase (SOD) and malondialdehyde (MDA). The biochemical indicators were measured with ELISA kits and the interactive effects were determined by isobole and polygonal analysis with Compusyn® computer software. The study revealed that oligopeptides did not decrease daphnid survival, only CYL inhibited this parameter, with synergistic effects when it was used as a component. The single metabolites at the two highest concentrations and all the binary and quadruple mixtures at all concentrations diminished GSH level, however both in the binary and in the quadruple mixtures most of the interactions between the metabolites were antagonistic. Nearly additive effects were found only in AER-A + CYL and MG-FR1+CYL. On the other hand, CAT activity was slightly increased in daphnids exposed to the binary mixtures with antagonistic interactions, however nearly addivive effects were found in animals exposed to the mixture of AER-A + ANA-A and synergistic in the quadruple mixture. SOD was elevated in daphnids exposed to single AER-A and MG-FR1, however it was diminished in the animals exposed to ANA-A and CYL. Binary mixtures in which CYL was present as a component decreased the level of this enzyme with nearly additive interactions in ANA-A + CYL. The quadruple mixture increased SOD level, with antagonistic interactions. Both single cyanobacterial metabolites, their binary and quadruple mixtures induced lipid peroxidation measured by MDA level and most of interactions in the binary mixtures were synergistic. The study suggested that antioxidative system of Daphnia magna responded to the tested metabolites and the real exposure to mixtures of these products may lead to various interactive effects with varied total toxicity.