To reduce the environmental damage caused by coal waste landfills, it is necessary to look for rational methods for their management. One method for their development is the creation of soil-like substrates. This study aimed to assess the properties of soil-like substrates from coal mining waste, combined with a varied sample of sewage sludge and waste mineral wool. The properties of the substrates were evaluated in a pot experiment. The properties of the substrates and their yield potential were determined. Coal mining waste as a substrate, compared to anthropogenic soil, was characterized by a significantly higher sorption capacity; the content of alkaline cations and pH; significantly higher contents of organic carbon, nitrogen, and available forms of K and Mg; and a lower content of available P. The substrates enriched with sewage sludge showed a significant increase in content of organic carbon, nitrogen, and assimilable forms of P and Mg, as well as the optimization of sorption properties. Extending the composition of substrates with mineral wool resulted in further improvement of their properties. The yields of plants grown on coal mining waste were significantly lower than those of those grown on anthropogenic soil. Substrates with sewage sludge and mineral wool had a significantly higher yield potential.