The research is aimed at creating a methodology for increasing the positioning accuracy of an industrial robot and minimizing the vibration of the robot gripper by applying machine learning based on the developed mathematical model for estimating the positioning error. Two components of positioning accuracy are considered: geometric and kinematic errors and elastic static deformations. The dynamic error in the partial system of motion of the robot manipulator links is analyzed. The equation of partial motions is obtained from Lagrange’s differential equation of motion of the II kind. The system of differential equations for the positioning error was solved analytically by Euler’s method. An example of modeling the position and orientation error of the gripper due to temperature deformations of the third link for the manipulator scheme is given. An example of the modeling of static deformations and errors of the manipulator with elastic pliability of the robot links is given. An example of dynamic error modeling in a partial system of motion of the robot links is given. The proposed method of modeling robot gripper positioning errors makes it possible to increase the positioning accuracy of the industrial robot and minimize the vibration of the gripper. Having a mathematical model of positioning errors, it is possible to compensate for the positioning error by changing the speed of movement of the gripper reference point before determining the direct kinematic task.