The work presents the results of research of compacted ceramic systems based on zirconium dioxide partially stabilized with cerium oxide and aluminium oxide, with additives of silicon carbide and silica; these materials could potentially be used as surgical implants or devices. The composite materials ZrO2–5wt.%CeO2–10wt.%SiC have shown higher biocompatibility with the human osteosarcoma cell line MG-63 than samples of compositions Al2O3–20wt.%SiO2–10wt.%ZrO2 and ZrO2–5wt.%CeO2. Samples demonstrated hydrophilic behavior according to contact angle measurements. Zeta potential experiments showed that the nanoparticles were negatively charged in all cases in this study. Since the samples compacted in the temperature range of 1300–1600°C are biocompatible with MG-63 cells, zirconia-based ceramics compacted at temperatures higher 1300°C may improve implant osseointegration as a result of further research.