Nitrogen is the most critical nutrient influencing both the quality and quantity of crop yield. It should be supplied in a rational manner to ensure its optimal uptake by plants while preventing excess accumulation in the soil profile. Although the mineral form of nitrogen is the most technologically convenient and allows for precise dosing tailored to the needs of specific crop species, its potential to leach into soil and groundwater has prompted the search for alternative yield-enhancing strategies in agricultural practice. This paper discusses the role of nitrogen in plant nutrition and its impact on soil health. It also presents alternative methods to mineral nitrogen fertilization, (including the use of organic, natural, and waste-derived fertilizers, as well as the cultivation of nitrogen-fixing pre-crop plants) additionally, it explores approaches for modifying plant metabolism through biostimulation with products containing humic acids, algae extracts, amino acids, and microorganisms. Reducing the accumulation of agriculture-derived pollutants in the natural environment is crucial for restoring the biological balance of ecosystems.