This article presents information on the presence of antibiotics in natural and organic fertilizers, as well as in arable soils and permanent grasslands, indicating that this is a significant problem especially for primary production stage in the agri-food chain. Interest in the presence of veterinary drugs in the environment has long been a relatively minor topic. In recent years, interest in this issue has increased significantly among scientists worldwide. Significant amounts of antibiotics have been detected in natural fertilizers from farm animals, primarily in large-scale farms. This has led to their uncontrolled introduction into soil and contamination of surface and groundwater with these compounds. This, in turn, can result in trace amounts of antibiotics in plant foods consumed by both humans and farm animals, posing a threat to the entire agri-food chain and public health protection