Agriculture has become a sector with a huge impact on the natural environment. The interest of agriculture in the category of innovative bio-stimulants is due to the intensive search for preparations based on natural substances. This is not possible without developing and implementing innovative technologies, e.g., cold plasma, along with innovative technologies supporting farmers. Therefore, given the need to prevent environmental damage caused by intensive agriculture, plant production and protection must be targeted at merging the stimulation of crop growth and the elimination of threats to humans and the environment. The analysis of how cold plasma can influence the production of organic bio-stimulants seems to be an unavoidable step in future approaches to this topic. Since allelopathic plants represent a source of many chemical compounds promoting crop growth and development, the coupling of biologically-active compound extraction with plasma activation of allelopathic extracts has interesting potential in offering the most modern alternative to conventional agriculture. However, its implementation in practice will only be feasible after a comprehensive and thoughtful investigation of the mechanisms behind crops’ response to such bio-stimulants.