The goal of sustainable and organic agriculture is to optimize the health and productivity of interdependent communities of soil life, plants, animals, and people. Organic plant production uses natural products and natural self-regulation processes occurring in the ecosystem. The availability of innovative applications and molecular techniques opens up new possibilities in the approach to plant protection for sustainable and organic agriculture. New strategies not only directly protect plants against pathogens but can also induce enhanced immunity that permanently protects against pathogenic strains. This review focuses on the bioactive properties of selected natural compounds (of plant and animal origin), their action on pathogens, and their roles in the mechanism of inducing plant resistance. The author presents selected activities of organic bioactive compounds, such as allicin, naringin, terpenes, laminarin, carrageenans, chitin and chitosan, and outlines the possibilities for their application in protecting crop plants against diseases. In addition, this mini review describes the mechanism of action of the above compounds as elicitors of defense reactions in the plant and the possibility of their utilization in the production of biological preparations as elements of a new plant protection strategy.