The purpose of this study was to determine the effectiveness of the operation of a novel installation for treating the outflow from a hybrid constructed wetland system and the possibility of domestic wastewater reuse. The study was carried out in 2022-2023 at a facility located in the Polesie National Park (PNP) in Poland. The analyzed installation for the treatment of wastewater discharged from the constructed wetland system is located in the basement of a single-family building and consists of a filtration system including: yarn, spun and carbon filters, and a UV lamp. In turn, the hybrid constructed wetland system from which the treated wastewater is recycled to the building consists of a 2-chamber primary settling tank and a system of two VF-HF type beds with common reed and willow. During the study period (October 2022 to December 2023), 14 series of analyses were performed, during which the values of selected physico-chemical and microbiological indicators were determined in the collected samples of treated wastewater. On the basis of the performed tests, it was found that the analyzed system provided an average efficiency of reduction of total suspended solids and BOD5 at 46.8 and 45.8%, respectively. Smaller effects were obtained for the reduction of COD (22.7%), total nitrogen (4.9%) and total phosphorus (16.3%). In contrast, the average reduction effects of microbiological indicators were very high, amounting to 92.7 and 97.1% for Escherichia coli and enteroccocus bacteria, respectively. The study showed that the effluent flowing out of the hybrid constructed wetland system after treatment in the analyzed installation could be reused for toilet flushing or green watering, as it usually did not contain microbiological contaminants. It was determined that the recycled treated wastewater could replace, on average, 18.7% of the good-quality water supplied by the mains water supply in the studied household.